AIXC Research / Publications
Publication Record

50+ Peer-Reviewed Papers.
ICLR 2026 Spotlight. 10 Venues.

Accepted at AAAI-26, ICLR 2026, NeurIPS 2025, Stanford, ELLIS, CIKM, IROS, and more. Publishing alongside Google DeepMind and OpenAI. Every entry linked to official conference evidence.

2026 50+ papers

ICLR 2026 — International Conference on Learning Representations 12 papers · 4 workshops Rio de Janeiro, April 2026
ICLR · Gen² WORKSHOP
Hierarchical Disease-State Generators for Neurodegenerative Genomics: A Benchmark Proposal for Intervention-Conditioned Multi-omic Generation
David Scott Lewis, Enrique Zueco
GenomicsAlzheimer'sMulti-omics
ICLR · Gen² WORKSHOP
Toward Generative Virtual Cells: Co-Evolving World Models and Perturbation Planners
David Scott Lewis, Enrique Zueco
Virtual CellsPerturbation PlanningWorld Models
ICLR · World Models WORKSHOP
Reinforcement Learning with World Models for Optimizing Alzheimer's Disease Treatment Timing and Dosing
David Scott Lewis, Enrique Zueco
Alzheimer'sRLTreatment Optimization
ICLR · World Models ORAL
Coherence-Validated Causal World Models for Multi-Scale Alzheimer's Disease Progression and Pharmacologic Reversal
David Scott Lewis, Enrique Zueco
Alzheimer'sCausal AIReversal Trajectories
ICLR · LM Reasoning WORKSHOP
Neuro-Symbolic Active Causal Hypothesis Testing for NAD+-Centered Alzheimer's Disease Reversal
David Scott Lewis, Enrique Zueco
Alzheimer'sNAD+Neuro-Symbolic
ICLR · LM Reasoning WORKSHOP
The AI Barrister Flight Simulator: A Neuro-Symbolic Benchmark for Structured Legal Reasoning
David Scott Lewis, Enrique Zueco, Haley Yi
Legal AINeuro-SymbolicBenchmark
ICLR · LM Reasoning WORKSHOP
Governed Self-Improvement for Logical Reasoning: Edit-Time Governance for Developmental Consistency
David Scott Lewis, Enrique Zueco
Self-ImprovementLogical ReasoningGovernance
ICLR · LM Reasoning ORAL
Latent-Implicit Thinking with Proof-Carrying Neuro-Symbolic Outputs for Biomedical Discovery
David Scott Lewis, Enrique Zueco
Biomedical AINeuro-SymbolicLatent Reasoning
ICLR · LM Reasoning ORAL
Autoformalizing Biomedical Text into Verified Knowledge Graph Reasoning: A Neuro-Symbolic Architecture for Alzheimer's Disease
David Scott Lewis, Enrique Zueco
Alzheimer'sKnowledge GraphsAutoformalization
ICLR · MLGenX WORKSHOP
Active Learning for Optimal Experimental Design in Alzheimer's Disease Drug Discovery: Prioritizing NAD+-Enhancing Therapeutic Analogs via Multi-Objective Bayesian Optimization
David Scott Lewis, Enrique Zueco
Alzheimer'sActive LearningNAD+
ICLR · MLGenX WORKSHOP
Agentic Active Causal Discovery for Alzheimer's Disease Reversal: Closing the Genomic Experimental Loop
David Scott Lewis, Enrique Zueco
Alzheimer'sCausal DiscoveryGenomics
ICLR · MLGenX WORKSHOP
Uncertainty-Aware Biomarker Discovery for Alzheimer's Disease Reversal: Bridging Mouse Models and Human Translation with Conformal Prediction
David Scott Lewis, Enrique Zueco
Alzheimer'sBiomarkersConformal Prediction
AAAI 2026 Workshops
AAAI-26 AIDD ORAL
Agentic Causal Graph Learning for Drug Target Discovery: A Self-Directed AI System at STRING Scale
David Scott Lewis, Enrique Zueco
Drug DiscoveryCausal GraphSTRING v12.0
AAAI-26 AIDD POSTER #31
The Algorithmic Alchemist: Advanced Generative AI Methodologies for De Novo Drug Design
David Scott Lewis, Enrique Zueco
Generative AIDe Novo Design
AAAI-26 AIDD POSTER #34
The Acceleration of Molecular Discovery through Advanced Active Learning and Bayesian Optimization
David Scott Lewis, Enrique Zueco
Active LearningBayesian Optimization
AAAI-26 AI4Research POSTER
Neural Cellular Automata and the PD-NCA AutoLab: A Differentiable Artificial Life Testbed for Autonomous Research Agents
David Scott Lewis, Enrique Zueco
Neural Cellular AutomataAutonomous Research
AAAI-26 AI4Research POSTER
The Trajectory of Graph of Thoughts: Advancing AI for Science through Structured, Verifiable, and Causal Reasoning
David Scott Lewis, Enrique Zueco
Graph of ThoughtsCausal Reasoning
AAAI-26 AI-LAW POSTER
Regulation-Aware Neuro-Symbolic Legal World Models for Cross-Border Commerce
David Scott Lewis, Enrique Zueco
Legal AINeuro-Symbolic
AAAI-26 FinAI POSTER
Polyculture Agents: Detecting and Mitigating Algorithmic Echo Chambers in Financial AI Workflows
David Scott Lewis, Anar Batkhuu, Enrique Zueco
Financial AIEcho Chambers
AAAI-26 LMReasoning ORAL
Neuro-Symbolic AI for Alzheimer's Disease: Physics-Informed Biomarker Prediction and Verifiable Intervention Planning
David Scott Lewis, Enrique Zueco
Alzheimer'sBiomarker Prediction
AAAI-26 LMReasoning POSTER
Glass-Box Arbitrators: An Explainable Neuro-Symbolic AI Framework for International Commercial Arbitration Proceedings
David Scott Lewis, Enrique Zueco
Explainable AIArbitration
AAAI-26 LMReasoning POSTER
Graph of Thoughts Nanobiomaterials Assistants: Towards Logical, Tool-Augmented, and Multi-Agent Reasoning in Scientific LLMs
David Scott Lewis, Enrique Zueco
NanobiomaterialsMulti-Agent
AAAI-26 LMReasoning POSTER
SOKRATES: Distilling Symbolic Knowledge into Option-Level Reasoning via Solver-Guided Preference Optimization
David Scott Lewis, Enrique Zueco
Symbolic KnowledgePreference Optimization

AI4X-AC 6 papers, 2 oral Applied AI for Science
AI4X-AC ORAL
Brain Resilience Modeling via Physics-Informed Neural Networks with Formal Verification
David Scott Lewis, Enrique Zueco
Brain ResiliencePhysics-Informed
AI4X-AC ORAL
High-Content Cell Painting Analysis with Causal Graph Learning for Drug Response Prediction
David Scott Lewis, Enrique Zueco
Cell PaintingCausal GraphDrug Response
AI4X-AC PAPER
AI-Optimized Cancer Treatment Scheduling with Verified Agentic Pipelines
David Scott Lewis, Enrique Zueco
Cancer TreatmentVAPTreatment Optimization
AI4X-AC PAPER
Physics-Informed Materials Property Prediction with Active Causal Hypothesis Testing
David Scott Lewis, Enrique Zueco
Materials ScienceACHT Framework
AI4X-AC PAPER
De Novo Molecular Design for Neurodegenerative Targets with Causal ADMET Optimization
David Scott Lewis, Enrique Zueco
De Novo DesignNeurodegenerative
AI4X-AC PAPER
Multi-Scale Toxicity Screening via Verified Agentic Pipelines for Pre-Clinical Safety
David Scott Lewis, Enrique Zueco
Toxicity PredictionVAPSafety

2025 7 papers + 1 invited talk
NeurIPS 2025 AI4D3 POSTER
Active Causal Hypothesis Testing for AI-Guided Drug Target Discovery
David Scott Lewis, Enrique Zueco
Drug DiscoveryCausal Hypothesis Testing
Stanford Agents4Science ACCEPTED
The Architectural Immune System: A Framework for Correcting Synthetic Fallacies in AI-Driven Science
David Scott Lewis, Anar Batkhuu, Haley Yi
Synthetic FallaciesAI Safety
ELLIS ML4Molecules POSTER #25
Physics-Informed Surrogates in a Verified Agentic Pipeline for Robust Molecular Simulation
David Scott Lewis, Enrique Zueco, Enrique Concha
Physics-InformedMolecular Simulation
CIKM 2025 FinAI PAPER #22
Algorithmic Echo Chambers: Interpretation Cascades, Model Risk Personas, and Systemic Risk in LLM-Driven Financial Workflows
Anar Batkhuu, David Scott Lewis, Enrique Zueco, Haley Yi
Echo ChambersSystemic Risk
CIKM 2025 FinAI PAPER #24
Verified LRM Agents for Finance: Economics-Informed World Models and Abstract Knowledge Management
David Scott Lewis, Anar Batkhuu, Haley Yi, Enrique Zueco, et al.
LRM AgentsWorld Models
CIKM 2025 FinAI PAPER #25
VAP: Preventing Plausibility Traps in Algorithmic Trading with Physics-Informed Learning and Formal Verification
David Scott Lewis, Enrique Zueco
VAPAlgorithmic Trading
IROS 2025 AIR4S INVITED SPEAKER
Building a Robot Scientist: From Reasoning Models to Autonomous Discovery
David Scott Lewis — Invited Talk (not a paper acceptance)
Robot ScientistAutonomous Discovery
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